Implantable bioartificial kidney
A compact implanted device could combine blood filtration with living kidney cells. Can it provide enough continuous function to replace dialysis safely for long periods?
Biomedical engineering
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Neural-implant lifetime testing
Can short laboratory tests predict how implanted brain electrodes will fail over years?
Noninvasive continuous glucose monitoring
Can a skin-worn sensor track glucose reliably over everyday life without repeated invasive calibration?
Small-diameter vascular grafts
Can a readily available artificial small artery remain open and remodel safely for long-term human use?
Deep-tissue sound printing
Sound can form injected materials inside tissue. How can a printer keep its pattern in the right place as deep tissue moves?
Wearable cardiac ultrasound
Wearable ultrasound can track deep tissues. How can heart measurements stay calibrated when a flexible array bends and its contact changes?
Closed-loop lower-limb neuroprostheses
Can an artificial leg return useful sensation and respond naturally to its user during unexpected movement?
Fully implantable speech neuroprostheses
Can a fully implanted wireless interface provide dependable everyday speech communication?
Long-read protein sequencing
Reading long, previously unknown proteins requires recognizing their chemical letters in order. Short-peptide identification is advancing; combining length, accuracy, speed and modified-letter recognition remains a demanding device target.
Human-scale organ cryopreservation
Rat kidneys have worked after cryogenic storage. Extending that success to a human-sized whole organ requires safe protective chemicals, ice-free cooling and uniform warming, followed by a demanding test of recovered function.
Implantable bioartificial pancreas
An implant can shelter insulin-producing cells and even generate oxygen for them. Can one retrievable device deliver a useful endocrine response at human scale while keeping its cells contained?
Microfluidic artificial lungs
Tiny blood channels can exchange enough oxygen to support a premature infant in a bench test. Can the complete device keep those channels open and compatible with blood during prolonged use?